Not really, businesses already won't hire you if you show up to your interview drunk. They don't care that it's legal. The chemicals in marijuana stay in your pee for a long time. The complications are going to be stuff like "Hello Job Man! I don't do drugs, but I smoked pot in Colorado on vacation, which is illegal here, but the chemicals are still in my drug test." "I don't do drugs, but I did drugs." Employee of the month. It's really simple, you want the job, don't smoke marijuana for a while. Not a problem if it's not addictive, eh?