HOLY SHIT GUYS.
I found one of those rooms that rerolls your items and then I got this
Spoiler http://cloud-4.steampowered.com/ugc/541883619704662657/4FF0176002319C96DCF3883590E2959D590D7E2E/
I was shooting a hail of mortar tears that EXPLODED and then divided into 4 smalled tears THAT EXPLODED AGAIN AND LEFT FIRE TRAILS
Isaac had no chance.
Spoiler http://cloud-2.steampowered.com/ugc/541883619704791401/849A6CEAC5F6C06D0F8F4CC72F55351B6954149E/